掌控结晶、喷雾干燥和氢化：Procegence 公司的多尺度和多物理场建模方法
原料药以及制剂使用复杂的单元工序进行制造，其中需要控制相间作用、反应和其他质量传递现象，以确定产品质量。上一代模型以简化的方式处理此行为。具有多相、多域和多物理场功能的计算流体力学 (CFD) 仿真是制药行业中的重要工具，它有助于优化设计和工作参数，以及扩展涉及多相的复杂工艺。
多相 CFD 在该领域的应用包括结晶、混合、干燥和不均匀反应等过程的建模，所有这些过程对于确保产品质量和一致性都至关重要。
通过精确模拟固相、液相和气相之间的相互作用，多相 CFD 可以更深入地了解质量传递、颗粒聚集、溶剂蒸发和化学反应等关键现象。这种洞察力可以优化工艺参数，优化量产和技术转移，减少开发时间和成本，同时提高制药的效率和稳健性。
随着制药行业的监管标准变得越来越严格，多相 CFD 的应用有望在确保合规性、提高整体过程可靠性以及生产质量一致的药物方面发挥重要作用。
在本次网络研讨会中，我们将讨论尺度相关现象和 Procegence 的实际用例所固有的挑战，并配有以下实践示例：
- 结晶
- 喷雾干燥
- 氢化
这些过程包括多个尺度相关现象（例如热量和质量传递及混合）和相间传递。复杂的多相系统在整个过程中也是瞬态的，对各种参数都很敏感。
我们的主讲嘉宾将讨论此类案例的 CFD 仿真和模型设置，并回顾其结果和优势。
今天就预订席位吧！
主讲嘉宾
Dr. Nima Yazdanpanah
Principal Consultant
Nima is a consultant specializing in advanced manufacturing, modeling, and simulation for the bio/pharmaceutical and fine chemical industries. His expertise includes process design, continuous manufacturing, simulation, particulate systems, digitalization, and regulatory compliance. With over 20 years of experience spanning pharmaceuticals, petrochemicals, specialty chemicals, and food industries, he has worked in R&D, process design, regulatory, and MSAT roles.
As the founder of Procegence (Process Intelligence), Nima helps clients optimize process development, scale-up, tech-transfer, and product launches, enabling faster, more cost-effective, and sustainable outcomes. Previously, he was a research scientist at the FDA, contributing to advancements in pharmaceutical manufacturing technologies.
Nima earned his PhD from The University of Sydney and completed postdoctoral research at MIT. He has received multiple awards, published extensively, holds two patent applications, and serves on advisory committees and review panels
Glenn Longwell
Portfolio Development Executive
After completing a BSc. in Chemical Engineering, Glenn Longwell has worked for over 39 years in the Computer Aided Engineering (CAE) space helping companies implement and gain value from physics-based simulations of their products and/or processes. At Siemens Digital Industries Software Glenn is responsible for the physics-based simulation portfolio (Simcenter) for the Pharmaceutical and Consumer Packaged Goods industries.