live webinar

Mastering crystallization, spray drying & hydrogenation: Procegence's approach with multiscale & multiphysics modeling

February 4, 2025 at 04:00 PM Coordinated Universal Time

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Pharmaceutical factory woman worker in protective clothing operating production line in sterile environment.

Drug substances, as well as formulations, are manufactured using complex unit operations where phase interactions, reactions and other mass transfer phenomena need to be controlled in order to ascertain product quality. Previous generation models treated this behavior in a simplified manner. Computational Fluid Dynamics (CFD) simulations with multiphase, multidomain and multiphysics capabilities is a crucial tool in the pharmaceutical industry, where it aids in the optimization of both design and operating parameters and scale-up of complex processes involving multiple phases.  

Applications of multiphase CFD in this field include the modeling of processes such as crystallization, mixing, drying and heterogeneous reactions, all of which are vital for ensuring product quality and consistency. 

By accurately simulating interactions between solid, liquid, and gas phases, multiphase CFD enables a deeper understanding of critical phenomena like mass transfer, particle aggregation, solvent evaporation, and chemical reactions. This insight allows for the optimization of process parameters, optimized scale-up and technology transfer, reducing development time and costs while enhancing the efficiency and robustness of pharmaceutical manufacturing.  

As regulatory standards in the pharmaceutical industry become increasingly stringent, the application of multiphase CFD is expected to play a significant role in ensuring compliance and improving overall process reliability and producing consistent quality medicines. 

In this webinar, we will discuss the challenges inherent in scale-dependent phenomena and a real use-case with Procegence, with the below examples from practice: 

  1. Crystallization
  2. Spray drying
  3. Hydrogenation

These processes include more than one scale-dependent phenomenon (e.g. heat and mass transfer and mixing) and phase transfer. Complex multiphase systems are also transient through the process and sensitive to various parameters.  

Our speakers will discuss CFD simulation and model setup for such cases and review the results and benefits.

Reserve your spot today! 

Meet the speakers

Procegence

Dr. Nima Yazdanpanah

Principal Consultant

Nima is a consultant specializing in advanced manufacturing, modeling, and simulation for the bio/pharmaceutical and fine chemical industries. His expertise includes process design, continuous manufacturing, simulation, particulate systems, digitalization, and regulatory compliance. With over 20 years of experience spanning pharmaceuticals, petrochemicals, specialty chemicals, and food industries, he has worked in R&D, process design, regulatory, and MSAT roles.

As the founder of Procegence (Process Intelligence), Nima helps clients optimize process development, scale-up, tech-transfer, and product launches, enabling faster, more cost-effective, and sustainable outcomes. Previously, he was a research scientist at the FDA, contributing to advancements in pharmaceutical manufacturing technologies.

Nima earned his PhD from The University of Sydney and completed postdoctoral research at MIT. He has received multiple awards, published extensively, holds two patent applications, and serves on advisory committees and review panels

Siemens

Glenn Longwell

Portfolio Development Executive

After completing a BSc. in Chemical Engineering, Glenn Longwell has worked for over 39 years in the Computer Aided Engineering (CAE) space helping companies implement and gain value from physics-based simulations of their products and/or processes. At Siemens Digital Industries Software Glenn is responsible for the physics-based simulation portfolio (Simcenter) for the Pharmaceutical and Consumer Packaged Goods industries.